Our Unique Offering

Two-Tier Metabolomics

A combined discovery-to-accredited-validation pipeline no single San Diego competitor currently offers in one engagement.

Discovery → Accredited Quantitation Pipeline

Tier 1 — Discovery

Untargeted HRMS

High-resolution mass spectrometry (HRMS) for untargeted metabolite profiling and biomarker discovery. Identifies novel candidates across the full metabolome without pre-selected targets.

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Tier 2 — Validation

ISO 17025 Targeted MRM

Sciex 4500 triple-quad MRM quantitation of confirmed candidates with full ISO 17025 method validation. Accredited COAs accepted for label claims, clinical submissions, and regulatory filings.

The Tier 1 HRMS discovery layer leverages our proteomics and LC-MS expertise alongside partner HRMS instrumentation. Tier 2 targeted MRM is performed entirely in-house on our Sciex 4500 under ISO 17025 accreditation — giving you discovery flexibility and regulatory-grade results in one engagement.

Test Panels

Targeted Metabolomics Menu

Validated MRM methods for the most analytically and commercially relevant metabolite classes. Custom panel development available.

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Amino Acid Profile

$300 – $500 / sample

Simultaneous quantitation of 40 amino acids including all essential amino acids (EAAs), branched-chain amino acids (BCAAs), and conditionally essential analytes by LC-MS/MS MRM.

40-analyte panel: EAAs, BCAAs, conditionally essential, and non-essential AAs
Sciex 4500 triple-quad MRM with isotope-labeled internal standards
Label claim quantitation for EAA/BCAA supplement products
Plasma, serum, urine, and dried blood spot matrices supported
Targets: sports nutrition brands, infant formula, clinical nutrition

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Acylcarnitine Panel

$300 – $450 / sample

Quantitation of free carnitine and acylcarnitine species (C0–C18) used as biomarkers for mitochondrial fatty acid oxidation, metabolic health, and sports performance research.

Free carnitine (C0) plus C2–C18 acylcarnitine species
Sciex 4500 MRM with precursor ion scanning and MRM confirmation
Plasma, serum, dried blood spot, and urine matrices
Inborn errors of metabolism screening and supplement efficacy endpoints
Targets: sports nutrition brands, clinical research, academic labs

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Targeted Custom Panel

$2,000 – $8,000 / project; $400–800 / sample ongoing

Full-scope custom metabolomics engagement — from HRMS-guided discovery to validated MRM method development and ongoing ISO 17025 accredited monitoring.

Untargeted HRMS discovery to identify candidate biomarkers
MRM method development and validation on Sciex 4500
ISO 17025 method validation report (accuracy, precision, linearity, LOQ)
Ongoing accredited testing once method is locked
Targets: pharma biomarker programs, nutraceutical efficacy, academic research

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Organic Acid Profile

$250 – $400 / sample

GC-MS based profiling of urinary and food matrix organic acids including TCA cycle intermediates, fermentation markers, and functional food quality indicators.

TMS/silylation derivatization + GC-MS analysis
TCA cycle acids: citrate, isocitrate, α-ketoglutarate, succinate, fumarate, malate
Fermentation markers: lactic acid, pyruvate, short-chain fatty acids
Urine, food matrix, fermentation broth, and cell culture supernatant
Targets: functional food, fermentation QC, clinical nutrition research

Instrumentation

Sciex 4500 Triple-Quad Platform

Our targeted metabolomics panel suite runs on the same Sciex 4500 LC-MS/MS system used for peptide characterization and mycotoxin testing — maximizing instrument utilization and accreditation scope.

Primary instrument	Sciex 4500 triple-quad LC-MS/MS
Acquisition mode	Multiple Reaction Monitoring (MRM)
LC system	Shimadzu UHPLC, C18 / HILIC columns
Internal standards	Stable-isotope labeled (SIL) for all MRM panels
Amino acid derivatization	AccQ-Tag / phenyl isothiocyanate (PITC)
Organic acid platform	GC-MS, TMS silylation (in-house)
Sample matrices	Plasma, serum, urine, DBS, food, fermentation broth
Calibration	Multi-point external + SIL internal standard bracketing
Method validation	ISO 17025 full validation (accuracy, precision, linearity, LOQ)
Accreditation	PJLA ISO/IEC 17025 — accredited scope

Sciex 4500 LC-MS/MS metabolomics platform at Prodigy Labs

Applications

Who Uses These Panels

Targeted metabolomics bridges nutrition science, clinical research, and pharmaceutical biomarker development — each with different documentation requirements that our accreditation satisfies.

Sports Nutrition Label Claims

EAA and BCAA supplement brands need accredited label claim testing for retail distribution and third-party certification programs. Our amino acid MRM panel delivers ISO 17025 COAs confirming declared analyte levels and ratios.

Clinical Nutrition Research

Infant formula, medical nutrition products, and enteral formulations require rigorous amino acid profiling for regulatory submissions and clinical trial endpoint documentation. GMP-adjacent documentation available.

Pharmaceutical Biomarker Programs

Pre-IND and Phase 1/2 studies using metabolite biomarkers need validated MRM methods with full traceability. Our custom panel development workflow takes you from HRMS discovery to validated quantitative method in a single engagement.

Nutraceutical Efficacy Studies

Demonstrate product efficacy through validated biomarker endpoints. We help nutraceutical brands design metabolomics sub-studies within clinical trials and provide the accredited COAs needed to support efficacy claims.

Functional Food & Fermentation QC

Organic acid profiling for fermented products, probiotic formulations, and functional ingredients. Monitor TCA cycle intermediates, fermentation markers, and organic acid signatures for lot-to-lot consistency and QC release testing.

Academic & CRO Research

Core metabolomics service for academic labs and contract research organizations needing accredited quantitative data alongside untargeted discovery. We bridge the gap between exploratory MS data and publication-grade validated measurements.

Who We Serve

Target Customers

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Sports Nutrition Brands

EAA/BCAA label claim COAs for retail and DTC channels. Accredited third-party verification for NSF, Informed Sport, and retailer requirements.

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Clinical Nutrition Companies

Infant formula and medical nutrition amino acid profiling. FDA/EFSA compliant documentation for clinical submissions.

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Pharma Biomarker Programs

Pre-IND metabolomics support. Validated MRM methods with ICH M10 bioanalytical method validation framework.

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Academic Core Labs

Outsource routine quantitative metabolomics to free your HRMS instrument time for discovery. Accredited data for grant reporting.

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Functional Food Producers

Fermentation QC and organic acid monitoring for probiotic and fermented food products. Lot release and shelf-life testing.

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Biotech / CRO

Metabolite endpoint quantitation for in vitro and in vivo studies. Combined discovery + MRM reporting in a single COA package.

What You Receive

Report Deliverables

Every targeted metabolomics report is accreditation-stamped with full method traceability, calibration records, and quantitative results.

ISO 17025-accredited COA with PJLA accreditation stamp
Quantitative results with units, calibration range, and LOQ for each analyte
MRM chromatograms for all quantifier and qualifier transitions
Calibration curve plots and r² values for each analyte
Isotope-labeled internal standard recovery table
Pass/Fail vs. label claim or client-specified acceptance criteria
Matrix spike recovery and QC sample results (for method validation reports)
Instrument calibration traceability and reference standard lot/purity information
Analyst and review signatures with report issue date
Method validation summary report (for custom panel development projects)

Targeted Metabolomics Testing

Two-Tier Metabolomics

Discovery → Accredited Quantitation Pipeline

Untargeted HRMS

ISO 17025 Targeted MRM

Targeted Metabolomics Menu

Amino Acid Profile

Acylcarnitine Panel

Targeted Custom Panel

Organic Acid Profile

Sciex 4500 Triple-Quad Platform

Who Uses These Panels

Sports Nutrition Label Claims

Clinical Nutrition Research

Pharmaceutical Biomarker Programs

Nutraceutical Efficacy Studies

Functional Food & Fermentation QC

Academic & CRO Research

Target Customers

Sports Nutrition Brands

Clinical Nutrition Companies

Pharma Biomarker Programs

Academic Core Labs

Functional Food Producers

Biotech / CRO

Report Deliverables

Ready to Start Your Metabolomics Project?

Two-Tier Metabolomics

Discovery → Accredited Quantitation Pipeline

Untargeted HRMS

ISO 17025 Targeted MRM

Targeted Metabolomics Menu

Amino Acid Profile

Acylcarnitine Panel

Targeted Custom Panel

Organic Acid Profile

Sciex 4500 Triple-Quad Platform

Who Uses These Panels

Sports Nutrition Label Claims

Clinical Nutrition Research

Pharmaceutical Biomarker Programs

Nutraceutical Efficacy Studies

Functional Food & Fermentation QC

Academic & CRO Research

Target Customers

Sports Nutrition Brands

Clinical Nutrition Companies

Pharma Biomarker Programs

Academic Core Labs

Functional Food Producers

Biotech / CRO

Report Deliverables

Ready to Start Your Metabolomics Project?

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