USP <467> compliant residual solvent testing for hard and soft gel capsules. Class 1, 2, and 3 solvent screening by headspace GC-MS.
Extraction solvents used in botanical and nutraceutical ingredient manufacturing can persist in finished capsule products.
Both hard gelatin and HPMC capsules can retain solvents from encapsulated ingredients.
Pharmaceutical and nutraceutical manufacturers cite USP <467> as the standard method for supplier and finished-product testing.
Static headspace GC-MS minimizes sample prep artifacts and provides reproducible results for low-volatility matrices.
2–3 business day rush available for urgent batch release decisions.
Full USP <467> Procedure A or B coverage depending on your solvent profile.
Submitting takes less than 5 minutes. Most projects turn around in 5–10 business days from sample receipt.
Fill out our sample intake form — sample type, quantity, and timeline. We confirm turnaround and quote within one business day.
We'll send submission instructions and our San Diego shipping address. Most samples ship ambient or cold depending on stability requirements.
Results are delivered as a signed PDF COA within the agreed turnaround. Rush service (2–3 business days) available for urgent timelines.
USP <467> Procedure A is a general screen for Class 1 and selected Class 2 solvents. Procedure B is used when specific solvents are known to be present from your manufacturing process. We can run either or both depending on your situation.
It's helpful but not required. Procedure A covers the most common solvents. If you know your process solvents, we can target them specifically for better sensitivity.
Typically 20–30 capsules or 3–5 grams of capsule fill material is sufficient. Contact us if your batch size is limited.
Submit your samples and receive an ISO 17025 accreditation pending Certificate of Analysis. Results in 5–10 business days.